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Case 215: voriconazole-induced periostitis.

Publication ,  Journal Article
Tailor, TD; Richardson, ML
Published in: Radiology
March 2015

History A 74-year-old woman presented with multifocal bone pain, including pain in multiple ribs, bilateral shoulders, and bilateral hips. The pain began several months before presentation and was quite severe, ultimately necessitating control with narcotics. At examination, strength in both lower extremities was slightly reduced, sensation and reflexes were intact, and range of motion was full, though painful. There were no notable constitutional symptoms of fever or weight loss. Laboratory work-up was remarkable for elevated alkaline phosphatase level (277 U/L [4.6 mkat/L]). The patient had undergone left lung transplantation 8 years prior for pulmonary fibrosis. A thorough pulmonary work-up for the cause of fibrosis, which included gathering an exposure, occupational, allergy, and previous infectious history, and a rheumatoid work-up were negative. The patient's posttransplantation course was complicated by bronchiolitis obliterans from chronic rejection and by recent pulmonary embolism, for which she was undergoing anticoagulation therapy at the time of presentation. Additionally, the patient experienced repeated pulmonary infections with Aspergillus, leading to multiple hospitalizations and long-term antifungal prophylaxis with voriconazole. A bone scan from an outside hospital was reviewed, and further imaging was performed.

Duke Scholars

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

March 2015

Volume

274

Issue

3

Start / End Page

930 / 935

Location

United States

Related Subject Headings

  • Voriconazole
  • Periostitis
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Female
  • Antifungal Agents
  • Aged
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Tailor, T. D., & Richardson, M. L. (2015). Case 215: voriconazole-induced periostitis. Radiology, 274(3), 930–935. https://doi.org/10.1148/radiol.14122800
Tailor, Tina D., and Michael L. Richardson. “Case 215: voriconazole-induced periostitis.Radiology 274, no. 3 (March 2015): 930–35. https://doi.org/10.1148/radiol.14122800.
Tailor TD, Richardson ML. Case 215: voriconazole-induced periostitis. Radiology. 2015 Mar;274(3):930–5.
Tailor, Tina D., and Michael L. Richardson. “Case 215: voriconazole-induced periostitis.Radiology, vol. 274, no. 3, Mar. 2015, pp. 930–35. Pubmed, doi:10.1148/radiol.14122800.
Tailor TD, Richardson ML. Case 215: voriconazole-induced periostitis. Radiology. 2015 Mar;274(3):930–935.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

March 2015

Volume

274

Issue

3

Start / End Page

930 / 935

Location

United States

Related Subject Headings

  • Voriconazole
  • Periostitis
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Female
  • Antifungal Agents
  • Aged
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences