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High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.

Publication ,  Journal Article
Phelps, JR; Russell, A; Lupa, MC; McNaull, P; Pittenger, S; Ricketts, K; Ditto, J; Bortsov, AV
Published in: Paediatr Anaesth
September 2015

BACKGROUND: The University of North Carolina's (UNC) Pediatric Sedation Service adopted a noninvasive procedural sedation protocol that uses dexmedetomidine in children based on review of literature that reported fast recovery times and low morbidity. This study aimed to compare dexmedetomidine discharge readiness times observed at UNC with those previously published with a hypothesis that the discharge times at UNC are longer than those previously published. A secondary aim was to evaluate the safety profile of the protocol. METHODS: Pediatric outpatients (6 months-18 years) who received dexmedetomidine per protocol for a noninvasive procedure or study from January 2011 through April 2012 were included in this retrospective chart review. A total of 615 patient encounters were evaluated. Patients received bolus doses of 2 μg·kg(-1) over 10 min for up to three doses followed by a 1 μg·kg(-1) ·h(-1) infusion (group 1) or a 1.5 μg·kg(-1) ·h(-1) infusion (group 2). Primary outcomes included time to sedation, time to arousal, and time to discharge. RESULTS: No significant differences between the dosing groups were noted. Time to discharge was significantly shorter for group 1 (79 min) than for group 2 (101 min). The range of discharge times at UNC was 78.7-100.9 min compared to previous studies that report recovery times of 24.8-35.2 min. CONCLUSION: Dexmedetomidine arousal and discharge times observed at UNC were longer than anticipated when compared to literature. The safety profile of the drug was comparable to prior studies.

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Published In

Paediatr Anaesth

DOI

EISSN

1460-9592

Publication Date

September 2015

Volume

25

Issue

9

Start / End Page

877 / 882

Location

France

Related Subject Headings

  • Time Factors
  • Retrospective Studies
  • Patient Discharge
  • Male
  • Infant
  • Hypnotics and Sedatives
  • Humans
  • Female
  • Dose-Response Relationship, Drug
  • Dexmedetomidine
 

Citation

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Phelps, J. R., Russell, A., Lupa, M. C., McNaull, P., Pittenger, S., Ricketts, K., … Bortsov, A. V. (2015). High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness. Paediatr Anaesth, 25(9), 877–882. https://doi.org/10.1111/pan.12569
Phelps, Janey R., Ali Russell, Maria C. Lupa, Peggy McNaull, Sara Pittenger, Karene Ricketts, Jennifer Ditto, and Andrey V. Bortsov. “High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.Paediatr Anaesth 25, no. 9 (September 2015): 877–82. https://doi.org/10.1111/pan.12569.
Phelps JR, Russell A, Lupa MC, McNaull P, Pittenger S, Ricketts K, et al. High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness. Paediatr Anaesth. 2015 Sep;25(9):877–82.
Phelps, Janey R., et al. “High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.Paediatr Anaesth, vol. 25, no. 9, Sept. 2015, pp. 877–82. Pubmed, doi:10.1111/pan.12569.
Phelps JR, Russell A, Lupa MC, McNaull P, Pittenger S, Ricketts K, Ditto J, Bortsov AV. High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness. Paediatr Anaesth. 2015 Sep;25(9):877–882.
Journal cover image

Published In

Paediatr Anaesth

DOI

EISSN

1460-9592

Publication Date

September 2015

Volume

25

Issue

9

Start / End Page

877 / 882

Location

France

Related Subject Headings

  • Time Factors
  • Retrospective Studies
  • Patient Discharge
  • Male
  • Infant
  • Hypnotics and Sedatives
  • Humans
  • Female
  • Dose-Response Relationship, Drug
  • Dexmedetomidine