Results of a pilot multicenter genotype-based randomized placebo-controlled trial of propranolol to reduce pain after major thermal burn injury.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Results of previous studies suggest that β-adrenoreceptor activation may augment pain, and that β-adrenoreceptor antagonists may be effective in reducing pain, particularly in individuals not homozygous for the catechol-O-methyltransferase (COMT) high-activity haplotype. MATERIALS AND METHODS: Consenting patients admitted for thermal burn injury at participating burn centers were genotyped; those who were not high-activity COMT homozygotes were randomized to propranolol 240 mg/d or placebo. Primary outcomes were study feasibility (consent rate, protocol completion rate) and pain scores on study days 5 to 19. Secondary outcomes assessed pain and posttraumatic stress disorder symptoms 6 weeks postinjury. RESULTS: Seventy-seven percent (61/79) of eligible patients were consented and genotyped, and 77% (47/61) were genotype eligible and randomized. Ninety-one percent (43/47) tolerated study drug and completed primary outcome assessments. In intention-to-treat and per-protocol analyses, patients randomized to propranolol had worse pain scores on study days 5 to 19. CONCLUSIONS: Genotype-specific pain medication interventions are feasible in hospitalized burn patients. Propranolol is unlikely to be a useful analgesic during the first few weeks after burn injury.

Full Text

Duke Authors

Cited Authors

  • Orrey, DC; Halawa, OI; Bortsov, AV; Shupp, JW; Jones, SW; Haith, LR; Hoskins, JM; Jordan, MH; Bangdiwala, SI; Roane, BR; Platts-Mills, TF; Holmes, JH; Hwang, J; Cairns, BA; McLean, SA

Published Date

  • January 2015

Published In

Volume / Issue

  • 31 / 1

Start / End Page

  • 21 - 29

PubMed ID

  • 25084070

Pubmed Central ID

  • PMC4260989

Electronic International Standard Serial Number (EISSN)

  • 1536-5409

Digital Object Identifier (DOI)

  • 10.1097/AJP.0000000000000086


  • eng

Conference Location

  • United States