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Infection-Induced Vascular Permeability Aids Mycobacterial Growth.

Publication ,  Journal Article
Oehlers, SH; Cronan, MR; Beerman, RW; Johnson, MG; Huang, J; Kontos, CD; Stout, JE; Tobin, DM
Published in: J Infect Dis
March 1, 2017

Pathogenic mycobacteria trigger formation of organized granulomas. As granulomas mature, they induce angiogenesis and vascular permeability. Here, in a striking parallel to tumor pro-angiogenic signaling, we identify angiopoietin-2 (ANG-2) induction as an important component of vascular dysfunction during mycobacterial infection. Mycobacterial infection in humans and zebrafish results in robust induction of ANG-2 expression from macrophages and stromal cells. Using a small-molecule inhibitor closely related to one currently in clinical trials, we link ANG-2/TIE2 signaling to vascular permeability during mycobacterial infection. Targeting granuloma-induced vascular permeability via vascular endothelial-protein tyrosine phosphatase inhibition limits mycobacterial growth, suggesting a new strategy for host-directed therapies against tuberculosis.

Duke Scholars

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

March 1, 2017

Volume

215

Issue

5

Start / End Page

813 / 817

Location

United States

Related Subject Headings

  • Zebrafish
  • Tuberculosis
  • Signal Transduction
  • Receptor, TIE-2
  • Mycobacterium Infections
  • Mycobacterium
  • Microbiology
  • Macrophages
  • Larva
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Oehlers, S. H., Cronan, M. R., Beerman, R. W., Johnson, M. G., Huang, J., Kontos, C. D., … Tobin, D. M. (2017). Infection-Induced Vascular Permeability Aids Mycobacterial Growth. J Infect Dis, 215(5), 813–817. https://doi.org/10.1093/infdis/jiw355
Oehlers, Stefan H., Mark R. Cronan, Rebecca W. Beerman, Matthew G. Johnson, Jianhua Huang, Christopher D. Kontos, Jason E. Stout, and David M. Tobin. “Infection-Induced Vascular Permeability Aids Mycobacterial Growth.J Infect Dis 215, no. 5 (March 1, 2017): 813–17. https://doi.org/10.1093/infdis/jiw355.
Oehlers SH, Cronan MR, Beerman RW, Johnson MG, Huang J, Kontos CD, et al. Infection-Induced Vascular Permeability Aids Mycobacterial Growth. J Infect Dis. 2017 Mar 1;215(5):813–7.
Oehlers, Stefan H., et al. “Infection-Induced Vascular Permeability Aids Mycobacterial Growth.J Infect Dis, vol. 215, no. 5, Mar. 2017, pp. 813–17. Pubmed, doi:10.1093/infdis/jiw355.
Oehlers SH, Cronan MR, Beerman RW, Johnson MG, Huang J, Kontos CD, Stout JE, Tobin DM. Infection-Induced Vascular Permeability Aids Mycobacterial Growth. J Infect Dis. 2017 Mar 1;215(5):813–817.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

March 1, 2017

Volume

215

Issue

5

Start / End Page

813 / 817

Location

United States

Related Subject Headings

  • Zebrafish
  • Tuberculosis
  • Signal Transduction
  • Receptor, TIE-2
  • Mycobacterium Infections
  • Mycobacterium
  • Microbiology
  • Macrophages
  • Larva
  • Humans