Laparoscopic anti-reflux surgery for idiopathic pulmonary fibrosis at a single centre.

Journal Article (Journal Article)

We sought to assess whether laparoscopic anti-reflux surgery (LARS) is associated with decreased rates of disease progression in patients with idiopathic pulmonary fibrosis (IPF).The study was a retrospective single-centre study of IPF patients with worsening symptoms and pulmonary function despite antacid treatment for abnormal acid gastro-oesophageal reflux. The period of exposure to LARS was September 1998 to December 2012. The primary end-point was a longitudinal change in forced vital capacity (FVC) % predicted in the pre- versus post-surgery periods.27 patients with progressive IPF underwent LARS. At time of surgery, the mean age was 65 years and mean FVC was 71.7% pred. Using a regression model, the estimated benefit of surgery in FVC % pred over 1 year was 5.7% (95% CI -0.9-12.2%, p=0.088) with estimated benefit in FVC of 0.22 L (95% CI -0.06-0.49 L, p=0.12). Mean DeMeester scores decreased from 42 to 4 (p<0.01). There were no deaths in the 90 days following surgery and 81.5% of participants were alive 2 years after surgery.Patients with IPF tolerated the LARS well. There were no statistically significant differences in rates of FVC decline pre- and post-LARS over 1 year; a possible trend toward stabilisation in observed FVC warrants prospective studies. The ongoing prospective randomised controlled trial will hopefully provide further insights regarding the safety and potential efficacy of LARS in IPF.

Full Text

Duke Authors

Cited Authors

  • Raghu, G; Morrow, E; Collins, BF; Ho, LAT; Hinojosa, MW; Hayes, JM; Spada, CA; Oelschlager, B; Li, C; Yow, E; Anstrom, KJ; Mart, D; Xiao, K; Pellegrini, CA

Published Date

  • September 2016

Published In

Volume / Issue

  • 48 / 3

Start / End Page

  • 826 - 832

PubMed ID

  • 27492835

Electronic International Standard Serial Number (EISSN)

  • 1399-3003

Digital Object Identifier (DOI)

  • 10.1183/13993003.00488-2016


  • eng

Conference Location

  • England