Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.

Journal Article (Journal Article)

AIMS: To investigate the relationship between omentin-1 levels and painful temporomandibular disorders (TMD). METHODS: In a case-control design, chronic painful TMD cases (n = 90) and TMD-free controls (n = 54) were selected from participants in the multisite OPPERA study (Orofacial Pain: Prospective Evaluation and Risk Assessment). Painful TMD case status was determined by examination using established Research Diagnostic Criteria for TMD (RDC/TMD). Levels of omentin-1 in stored blood plasma samples were measured by using an enzyme linked immunosorbent assay. Binary logistic regression was used to calculate the odds ratios (ORs) and 95% confidence limits (CLs) for the association between omentin-1 and painful TMD. Models were adjusted for study site, age, sex, and body mass index. RESULTS: The unadjusted association between omentin-1 and chronic painful TMD was statistically nonsignificant (P = .072). Following adjustment for covariates, odds of TMD pain decreased 36% per standard deviation increase in circulating omentin-1 (adjusted OR = 0.64; 95% CL: 0.43, 0.96; P = .031). CONCLUSION: Circulating levels of omentin-1 were significantly lower in painful TMD cases than controls, suggesting that TMD pain is mediated by inflammatory pathways.

Full Text

Duke Authors

Cited Authors

  • Harmon, JB; Sanders, AE; Wilder, RS; Essick, GK; Slade, GD; Hartung, JE; Nackley, AG

Published Date

  • 2016

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 203 - 209

PubMed ID

  • 27472522

Pubmed Central ID

  • PMC4998962

International Standard Serial Number (ISSN)

  • 2333-0384

Digital Object Identifier (DOI)

  • 10.11607/ofph.1608


  • eng

Conference Location

  • United States