A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection.

Journal Article

Currently there are no approved vaccines or specific therapies to prevent or treat Zika virus (ZIKV) infection. We interrogated a library of FDA-approved drugs for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7). More than 20 out of 774 tested compounds decreased ZIKV infection in our in vitro screening assay. Selected compounds were further validated for inhibition of ZIKV infection in human cervical, placental, and neural stem cell lines, as well as primary human amnion cells. Established anti-flaviviral drugs (e.g., bortezomib and mycophenolic acid) and others that had no previously known antiviral activity (e.g., daptomycin) were identified as inhibitors of ZIKV infection. Several drugs reduced ZIKV infection across multiple cell types. This study identifies drugs that could be tested in clinical studies of ZIKV infection and provides a resource of small molecules to study ZIKV pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Barrows, NJ; Campos, RK; Powell, ST; Prasanth, KR; Schott-Lerner, G; Soto-Acosta, R; Galarza-Muñoz, G; McGrath, EL; Urrabaz-Garza, R; Gao, J; Wu, P; Menon, R; Saade, G; Fernandez-Salas, I; Rossi, SL; Vasilakis, N; Routh, A; Bradrick, SS; Garcia-Blanco, MA

Published Date

  • August 2016

Published In

Volume / Issue

  • 20 / 2

Start / End Page

  • 259 - 270

PubMed ID

  • 27476412

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

International Standard Serial Number (ISSN)

  • 1931-3128

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2016.07.004

Language

  • eng