Mean First-Passage Times in Biology.


Journal Article

Many biochemical processes, such as charge hopping or protein folding, can be described by an average timescale to reach a final state, starting from an initial state. Here, we provide a pedagogical treatment of the mean first-passage time (MFPT) of a physical process, which depends on the number of intervening states between the initial state and the target state. Our aim in this tutorial review is to provide a clear development of the mean first-passage time formalism and to show some of its practical utility. The MFPT treatment can provide a useful link between microscopic rates and the average timescales often probed by experiment.

Full Text

Duke Authors

Cited Authors

  • Polizzi, NF; Therien, MJ; Beratan, DN

Published Date

  • November 2016

Published In

Volume / Issue

  • 56 / 9-10

Start / End Page

  • 816 - 824

PubMed ID

  • 29081538

Pubmed Central ID

  • 29081538

Electronic International Standard Serial Number (EISSN)

  • 1869-5868

International Standard Serial Number (ISSN)

  • 0021-2148

Digital Object Identifier (DOI)

  • 10.1002/ijch.201600040


  • eng