Cholinergic Circuit Control of Postnatal Neurogenesis.
Published
Journal Article
New neuron addition via continued neurogenesis in the postnatal/adult mammalian brain presents a distinct form of nervous system plasticity. During embryonic development, precise temporal and spatial patterns of neurogenesis are necessary to create the nervous system architecture. Similar between embryonic and postnatal stages, neurogenic proliferation is regulated by neural stem cell (NSC)-intrinsic mechanisms layered upon cues from their local microenvironmental niche. Following developmental assembly, it remains relatively unclear what may be the key driving forces that sustain continued production of neurons in the postnatal/adult brain. Recent experimental evidence suggests that patterned activity from specific neural circuits can also directly govern postnatal/adult neurogenesis. Here, we review experimental findings that revealed cholinergic modulation, and how patterns of neuronal activity and acetylcholine release may differentially or synergistically activate downstream signaling in NSCs. Higher-order excitatory and inhibitory inputs regulating cholinergic neuron firing, and their implications in neurogenesis control are also considered.
Full Text
Duke Authors
Cited Authors
- Asrican, B; Paez-Gonzalez, P; Erb, J; Kuo, CT
Published Date
- 2016
Published In
Volume / Issue
- 3 / 1
PubMed ID
- 27468423
Pubmed Central ID
- 27468423
International Standard Serial Number (ISSN)
- 2326-2133
Digital Object Identifier (DOI)
- 10.1080/23262133.2015.1127310
Language
- eng
Conference Location
- England