High-throughput acoustic separation of platelets from whole blood.

Journal Article (Journal Article)

Platelets contain growth factors which are important in biomedical and clinical applications. In this work, we present an acoustic separation device for high-throughput, non-invasive platelet isolation. In particular, we separated platelets from whole blood at a 10 mL min(-1) throughput, which is three orders of magnitude greater than that of existing acoustic-based platelet separation techniques. Without sample dilution, we observed more than 80% RBC/WBC removal and platelet recovery. High throughput, high separation efficiency, and biocompatibility make this device useful for many clinical applications.

Full Text

Duke Authors

Cited Authors

  • Chen, Y; Wu, M; Ren, L; Liu, J; Whitley, PH; Wang, L; Huang, TJ

Published Date

  • September 2016

Published In

Volume / Issue

  • 16 / 18

Start / End Page

  • 3466 - 3472

PubMed ID

  • 27477388

Pubmed Central ID

  • PMC5010861

Electronic International Standard Serial Number (EISSN)

  • 1473-0189

International Standard Serial Number (ISSN)

  • 1473-0197

Digital Object Identifier (DOI)

  • 10.1039/c6lc00682e

Language

  • eng