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Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model.

Publication ,  Journal Article
Pasciak, AS; Bourgeois, AC; Paxton, BE; Nodit, L; Coan, PN; Kraitchman, D; Stinnett, SS; Patel, VM; Fu, Y; Adams, JK; Tolbert, MK; Lux, CN ...
Published in: J Vasc Interv Radiol
October 2016

PURPOSE: To evaluate feasibility of left gastric artery (LGA) yttrium-90 ((90)Y) radioembolization as potential treatment for obesity in a porcine model. MATERIALS AND METHODS: This study included 8 young female pigs (12-13 weeks, 21.8-28.1 kg). Six animals received infusions of (90)Y resin microspheres (46.3-105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69-74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed. RESULTS: Superficial mucosal ulcerations < 3.0 cm(2) were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg ± 5.4 vs 54.7 kg ± 6.5, P = .053). Average fundic parietal area (165 cm(2) vs 282 cm(2), P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24). CONCLUSIONS: LGA (90)Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.

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Published In

J Vasc Interv Radiol

DOI

EISSN

1535-7732

Publication Date

October 2016

Volume

27

Issue

10

Start / End Page

1509 / 1517

Location

United States

Related Subject Headings

  • Yttrium Radioisotopes
  • Weight Loss
  • Time Factors
  • Sus scrofa
  • Stomach
  • Radiopharmaceuticals
  • Pilot Projects
  • Obesity
  • Nuclear Medicine & Medical Imaging
  • Models, Animal
 

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Pasciak, A. S., Bourgeois, A. C., Paxton, B. E., Nodit, L., Coan, P. N., Kraitchman, D., … Bradley, Y. C. (2016). Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model. J Vasc Interv Radiol, 27(10), 1509–1517. https://doi.org/10.1016/j.jvir.2016.05.020
Pasciak, Alexander S., Austin C. Bourgeois, Ben E. Paxton, Laurentia Nodit, Patricia N. Coan, Dara Kraitchman, Sandra S. Stinnett, et al. “Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model.J Vasc Interv Radiol 27, no. 10 (October 2016): 1509–17. https://doi.org/10.1016/j.jvir.2016.05.020.
Pasciak AS, Bourgeois AC, Paxton BE, Nodit L, Coan PN, Kraitchman D, et al. Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model. J Vasc Interv Radiol. 2016 Oct;27(10):1509–17.
Pasciak, Alexander S., et al. “Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model.J Vasc Interv Radiol, vol. 27, no. 10, Oct. 2016, pp. 1509–17. Pubmed, doi:10.1016/j.jvir.2016.05.020.
Pasciak AS, Bourgeois AC, Paxton BE, Nodit L, Coan PN, Kraitchman D, Stinnett SS, Patel VM, Fu Y, Adams JK, Tolbert MK, Lux CN, Arepally A, Bradley YC. Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model. J Vasc Interv Radiol. 2016 Oct;27(10):1509–1517.
Journal cover image

Published In

J Vasc Interv Radiol

DOI

EISSN

1535-7732

Publication Date

October 2016

Volume

27

Issue

10

Start / End Page

1509 / 1517

Location

United States

Related Subject Headings

  • Yttrium Radioisotopes
  • Weight Loss
  • Time Factors
  • Sus scrofa
  • Stomach
  • Radiopharmaceuticals
  • Pilot Projects
  • Obesity
  • Nuclear Medicine & Medical Imaging
  • Models, Animal