Role of C1q complement fixing antibody assay in therapeutic plasma exchange management of pediatric cardiac antibody mediated rejection.


Journal Article

Pediatric cardiac transplant patients with antibody-mediated rejection (AMR) often undergo therapeutic plasma exchange (TPE) to remove pathologic donor specific antibodies (DSA). In cases where DSA persist, it is unclear how long TPE should be continued. We report a case of a 17-year-old cardiac transplant patient with AMR where use of a C1q complement fixing antibody assay helped guide TPE cessation. This report adds to the existing literature that highlights the potential clinical significance of C1q antibodies in AMR management.

Full Text

Duke Authors

Cited Authors

  • Onwuemene, OA; Heath, DM; Hartman, C; Wong, ECC

Published Date

  • August 2017

Published In

Volume / Issue

  • 32 / 4

Start / End Page

  • 279 - 281

PubMed ID

  • 27475847

Pubmed Central ID

  • 27475847

Electronic International Standard Serial Number (EISSN)

  • 1098-1101

Digital Object Identifier (DOI)

  • 10.1002/jca.21488


  • eng

Conference Location

  • United States