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Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.

Publication ,  Journal Article
Gray, TK; Lipes, B; Linkhart, T; Mohan, S; Baylink, D
Published in: Connect Tissue Res
1989

A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin.

Duke Scholars

Published In

Connect Tissue Res

DOI

ISSN

0300-8207

Publication Date

1989

Volume

20

Issue

1-4

Start / End Page

23 / 32

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Transforming Growth Factors
  • Rats
  • Osteosarcoma
  • Osteoblasts
  • Estrogens
  • Estradiol
  • Cell Division
  • Biochemistry & Molecular Biology
  • Animals
 

Citation

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ICMJE
MLA
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Gray, T. K., Lipes, B., Linkhart, T., Mohan, S., & Baylink, D. (1989). Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. Connect Tissue Res, 20(1–4), 23–32. https://doi.org/10.3109/03008208909023871
Gray, T. K., B. Lipes, T. Linkhart, S. Mohan, and D. Baylink. “Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.Connect Tissue Res 20, no. 1–4 (1989): 23–32. https://doi.org/10.3109/03008208909023871.
Gray TK, Lipes B, Linkhart T, Mohan S, Baylink D. Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. Connect Tissue Res. 1989;20(1–4):23–32.
Gray, T. K., et al. “Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.Connect Tissue Res, vol. 20, no. 1–4, 1989, pp. 23–32. Pubmed, doi:10.3109/03008208909023871.
Gray TK, Lipes B, Linkhart T, Mohan S, Baylink D. Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. Connect Tissue Res. 1989;20(1–4):23–32.
Journal cover image

Published In

Connect Tissue Res

DOI

ISSN

0300-8207

Publication Date

1989

Volume

20

Issue

1-4

Start / End Page

23 / 32

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Transforming Growth Factors
  • Rats
  • Osteosarcoma
  • Osteoblasts
  • Estrogens
  • Estradiol
  • Cell Division
  • Biochemistry & Molecular Biology
  • Animals