Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.

Journal Article

A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin.

Full Text

Duke Authors

Cited Authors

  • Gray, TK; Lipes, B; Linkhart, T; Mohan, S; Baylink, D

Published Date

  • January 1989

Published In

Volume / Issue

  • 20 / 1-4

Start / End Page

  • 23 - 32

PubMed ID

  • 2612155

Electronic International Standard Serial Number (EISSN)

  • 1607-8438

International Standard Serial Number (ISSN)

  • 0300-8207

Digital Object Identifier (DOI)

  • 10.3109/03008208909023871

Language

  • eng