Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.
Publication
, Journal Article
Gray, TK; Lipes, B; Linkhart, T; Mohan, S; Baylink, D
Published in: Connect Tissue Res
1989
A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin.
Duke Scholars
Published In
Connect Tissue Res
DOI
ISSN
0300-8207
Publication Date
1989
Volume
20
Issue
1-4
Start / End Page
23 / 32
Location
England
Related Subject Headings
- Tumor Cells, Cultured
- Transforming Growth Factors
- Rats
- Osteosarcoma
- Osteoblasts
- Estrogens
- Estradiol
- Cell Division
- Biochemistry & Molecular Biology
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Gray, T. K., Lipes, B., Linkhart, T., Mohan, S., & Baylink, D. (1989). Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. Connect Tissue Res, 20(1–4), 23–32. https://doi.org/10.3109/03008208909023871
Gray, T. K., B. Lipes, T. Linkhart, S. Mohan, and D. Baylink. “Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.” Connect Tissue Res 20, no. 1–4 (1989): 23–32. https://doi.org/10.3109/03008208909023871.
Gray TK, Lipes B, Linkhart T, Mohan S, Baylink D. Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. Connect Tissue Res. 1989;20(1–4):23–32.
Gray, T. K., et al. “Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth.” Connect Tissue Res, vol. 20, no. 1–4, 1989, pp. 23–32. Pubmed, doi:10.3109/03008208909023871.
Gray TK, Lipes B, Linkhart T, Mohan S, Baylink D. Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. Connect Tissue Res. 1989;20(1–4):23–32.
Published In
Connect Tissue Res
DOI
ISSN
0300-8207
Publication Date
1989
Volume
20
Issue
1-4
Start / End Page
23 / 32
Location
England
Related Subject Headings
- Tumor Cells, Cultured
- Transforming Growth Factors
- Rats
- Osteosarcoma
- Osteoblasts
- Estrogens
- Estradiol
- Cell Division
- Biochemistry & Molecular Biology
- Animals