Is there an association between HIV-1 genital shedding and cervical intraepithelial neoplasia 2/3 among women on antiretroviral therapy?

Published

Journal Article

OBJECTIVE: Given the high prevalence of cervical intraepithelial neoplasia (CIN) grade 2/3 among HIV-infected women, we sought to examine the relationship between CIN 2/3 and HIV-1 genital shedding among women on highly active antiretroviral therapy (HAART). MATERIALS AND METHODS: Paired plasma and cervical wick specimens for HIV-1 RNA measurements were obtained from 44 HIV-infected women with biopsy-confirmed CIN 2/3 (cases) and 44 age-matched HIV-infected women with normal cervical findings on colposcopy (controls). All subjects tested negative for sexually transmitted infections and had been stable on HAART for at least 3 months. HIV-1 viral load was measured in both blood and cervical specimens using commercial real-time polymerase chain reaction assays. RESULTS: Cervical intraepithelial neoplasia 2/3 was not significantly associated with the detection or magnitude of plasma or cervical HIV-1 RNA shedding. HIV was detected in the plasma in 10 cases (23%) and 10 controls (25%) (odds ratio = 1.0; 95% confidence interval = 0.33-3.1). Cervical HIV-1 was detected in 6 cases (13.6%) and 9 controls (20.4%) (odds ratio = 0.61; 95% confidence interval = 0.20-1.90). Mean HIV-1 concentration in cervical secretions among women with CIN 2/3 who shed was 2.93 log10 copies versus 2.72 among controls (p = .65). CONCLUSIONS: Among women on HAART, we found no relationship between CIN 2/3 and HIV-1 genital shedding.

Full Text

Duke Authors

Cited Authors

  • Huchko, MJ; Woo, V; Liegler, T; Leddy, A; Smith-McCune, K; Sawaya, GF; Bukusi, EA; Cohen, CR

Published Date

  • July 2013

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 354 - 360

PubMed ID

  • 23486070

Pubmed Central ID

  • 23486070

Electronic International Standard Serial Number (EISSN)

  • 1526-0976

Digital Object Identifier (DOI)

  • 10.1097/LGT.0b013e3182712286

Language

  • eng

Conference Location

  • United States