Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period.

Published

Journal Article

BACKGROUND AND OBJECTIVE: Prior studies have suggested that after stroke there is a time-limited period of increased responsiveness to training as a result of heightened plasticity-a sensitive period thought to be induced by ischemia itself. Using a mouse model, we have previously shown that most training-associated recovery after a caudal forelimb area (CFA) stroke occurs in the first week and is attributable to reorganization in a medial premotor area (AGm). The existence of a stroke-induced sensitive period leads to the counterintuitive prediction that a second stroke should reopen this window and promote full recovery from the first stroke. To test this prediction, we induced a second stroke in the AGm of mice with incomplete recovery after a first stroke in CFA. METHODS: Mice were trained to perform a skilled prehension (reach-to-grasp) task to an asymptotic level of performance, after which they underwent photocoagulation-induced stroke in CFA. After a 7-day poststroke delay, the mice were then retrained to asymptote. We then induced a second stroke in the AGm, and after only a 1-day delay, retrained the mice. RESULTS: Recovery of prehension was incomplete when training was started after a 7-day poststroke delay and continued for 19 days. However, a second focal stroke in the AGm led to a dramatic response to 9 days of training, with full recovery to normal levels of performance. CONCLUSIONS: New ischemia can reopen a sensitive period of heightened responsiveness to training and mediate full recovery from a previous stroke.

Full Text

Duke Authors

Cited Authors

  • Zeiler, SR; Hubbard, R; Gibson, EM; Zheng, T; Ng, K; O'Brien, R; Krakauer, JW

Published Date

  • September 2016

Published In

Volume / Issue

  • 30 / 8

Start / End Page

  • 794 - 800

PubMed ID

  • 26721868

Pubmed Central ID

  • 26721868

Electronic International Standard Serial Number (EISSN)

  • 1552-6844

Digital Object Identifier (DOI)

  • 10.1177/1545968315624783

Language

  • eng

Conference Location

  • United States