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Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis.

Publication ,  Journal Article
Ladapo, JA; Blecker, S; O'Donnell, M; Jumkhawala, SA; Douglas, PS
Published in: PLoS One
2016

BACKGROUND: Appropriate use criteria (AUC) for cardiac stress tests address concerns about utilization growth and patient safety. We systematically reviewed studies of appropriateness, including within physician specialties; evaluated trends over time and in response to AUC updates; and characterized leading indications for inappropriate/rarely appropriate testing. METHODS: We searched PubMed (2005-2015) for English-language articles reporting stress echocardiography or myocardial perfusion imaging (MPI) appropriateness. Data were pooled using random-effects meta-analysis and meta-regression. RESULTS: Thirty-four publications of 41,578 patients were included, primarily from academic centers. Stress echocardiography appropriate testing rates were 53.0% (95% CI, 45.3%-60.7%) and 50.9% (42.6%-59.2%) and inappropriate/rarely appropriate rates were 19.1% (11.4%-26.8%) and 28.4% (23.9%-32.8%) using 2008 and 2011 AUC, respectively. Stress MPI appropriate testing rates were 71.1% (64.5%-77.7%) and 72.0% (67.6%-76.3%) and inappropriate/rarely appropriate rates were 10.7% (7.2%-14.2%) and 15.7% (12.4%-19.1%) using 2005 and 2009 AUC, respectively. There was no significant temporal trend toward rising rates of appropriateness for stress echocardiography or MPI. Unclassified stress echocardiograms fell by 79% (p = 0.04) with updated AUC. There were no differences between cardiac specialists and internists. CONCLUSIONS: Rates of appropriate use tend to be lower for stress echocardiography compared to MPI, and updated AUC reduced unclassified stress echocardiograms. There is no conclusive evidence that AUC improved appropriate use over time. Further research is needed to determine if integration of appropriateness guidelines in academic and community settings is an effective approach to optimizing inappropriate/rarely appropriate use of stress testing and its associated costs and patient harms.

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

8

Start / End Page

e0161153

Location

United States

Related Subject Headings

  • Practice Guidelines as Topic
  • Patient Safety
  • Myocardial Perfusion Imaging
  • Humans
  • General Science & Technology
  • Exercise Test
  • Echocardiography
  • Coronary Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ladapo, J. A., Blecker, S., O’Donnell, M., Jumkhawala, S. A., & Douglas, P. S. (2016). Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis. PLoS One, 11(8), e0161153. https://doi.org/10.1371/journal.pone.0161153
Ladapo, Joseph A., Saul Blecker, Michael O’Donnell, Saahil A. Jumkhawala, and Pamela S. Douglas. “Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis.PLoS One 11, no. 8 (2016): e0161153. https://doi.org/10.1371/journal.pone.0161153.
Ladapo JA, Blecker S, O’Donnell M, Jumkhawala SA, Douglas PS. Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis. PLoS One. 2016;11(8):e0161153.
Ladapo, Joseph A., et al. “Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis.PLoS One, vol. 11, no. 8, 2016, p. e0161153. Pubmed, doi:10.1371/journal.pone.0161153.
Ladapo JA, Blecker S, O’Donnell M, Jumkhawala SA, Douglas PS. Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis. PLoS One. 2016;11(8):e0161153.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

8

Start / End Page

e0161153

Location

United States

Related Subject Headings

  • Practice Guidelines as Topic
  • Patient Safety
  • Myocardial Perfusion Imaging
  • Humans
  • General Science & Technology
  • Exercise Test
  • Echocardiography
  • Coronary Disease