Genetic Susceptibility to Fungal Infections: What is in the Genes?

Published

Journal Article

The development of severe fungal infections has long been associated with traditional risk factors such as profound immunosuppression, yet it remains challenging to understand why under similar conditions only some patients will develop these infections while others will not. Recent studies have demonstrated the importance of host genetic variation in influencing the severity and susceptibility to invasive fungal infections (IFIs). In this review, we examine selected primary immunodeficiencies characterized by their vulnerability to a narrow range of fungal pathogens, and then focus on recently identified genetic polymorphisms associated with an increased susceptibility to IFIs.

Full Text

Duke Authors

Cited Authors

  • Maskarinec, SA; Johnson, MD; Perfect, JR

Published Date

  • June 2016

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 81 - 91

PubMed ID

  • 27547700

Pubmed Central ID

  • 27547700

International Standard Serial Number (ISSN)

  • 2196-5471

Digital Object Identifier (DOI)

  • 10.1007/s40588-016-0037-3

Language

  • eng

Conference Location

  • Switzerland