Patient preferences and linear scoring rules for patient-reported outcomes.

Journal Article (Journal Article)

BACKGROUND: : Many patient-reported outcomes (PRO) instruments are scored by averaging or summing Likert category values over all items or domains of the elicitation instrument, yielding domain-specific scores or a total score for the entire instrument. OBJECTIVE: : To evaluate differences between conventional linear and preference-weighted scores for PRO instruments used in asthma, oncology, and obesity. METHODS: : We estimated preference-weighted scores for all the items and response categories in the Onset-of-Effect Questionnaire (OEQ), the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30, and the Impact of Weight on Quality of Life Questionnaire-Lite version (IWQOL-Lite) using choice-format conjoint analysis, known also as discrete-choice experiments. RESULTS: : Conventional linear scoring rules can overstate the relative importance to patients of improvements in some domains and understate the relative importance of improvements in other domains. CONCLUSIONS: : Patient preference-weighted scores estimated by conjoint-analysis methods allow for non-linearities and account for the relative contribution of individual items and domains to patient well-being. Conventional linear scores and preference-weighted scores can result in different conclusions about the size of patient-reported treatment effects.

Full Text

Duke Authors

Cited Authors

  • Mohamed, AF; Hauber, AB; Johnson, FR; Coon, CD

Published Date

  • December 1, 2010

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 217 - 227

PubMed ID

  • 22273431

International Standard Serial Number (ISSN)

  • 1178-1653

Digital Object Identifier (DOI)

  • 10.2165/11537880-000000000-00000


  • eng

Conference Location

  • New Zealand