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Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).

Publication ,  Journal Article
Parikh, KS; Coles, A; Schulte, PJ; Kraus, WE; Fleg, JL; Keteyian, SJ; Piña, IL; Fiuzat, M; Whellan, DJ; O'Connor, CM; Mentz, RJ
Published in: Am J Cardiol
October 15, 2016

Angina pectoris (AP) is associated with worse outcomes in heart failure (HF). We investigated the association of AP with health-related quality of life (HRQoL), exercise capacity, and clinical outcomes and its interaction with exercise training in an HF population. We grouped 2,331 patients with HF with reduced ejection fraction in the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) trial of usual care ± exercise training according to whether they had self-reported AP by Canadian classification score. HRQoL and clinical outcomes were assessed by AP status. In HF-ACTION, 406 patients (17%) had AP at baseline (44% with Canadian classification score ≥II) with HF severity similar to those without AP. Patients with AP had similar baseline exercise capacity but worse depressive symptoms and HRQoL. AP was associated with 22% greater adjusted risk for all-cause mortality/hospitalizations, driven by hospitalizations. There was significant interaction between baseline AP and exercise training peak VO2 change (p = 0.019) but not other end points. Exercise training was associated with greater peak VO2 improvement after 3 months in patients with AP (treatment effect = 1.25 ml/kg/min, 95% CI 0.6 to 1.9). In conclusion, AP was associated with worse HRQoL and depressive symptoms. Despite greater peak VO2 improvement with exercise training, patients with AP experienced more adverse outcomes.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 15, 2016

Volume

118

Issue

8

Start / End Page

1211 / 1216

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Quality of Life
  • Proportional Hazards Models
  • Prognosis
  • Oxygen Consumption
  • Mortality
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Parikh, K. S., Coles, A., Schulte, P. J., Kraus, W. E., Fleg, J. L., Keteyian, S. J., … Mentz, R. J. (2016). Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION). Am J Cardiol, 118(8), 1211–1216. https://doi.org/10.1016/j.amjcard.2016.07.040
Parikh, Kishan S., Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, Ileana L. Piña, et al. “Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).Am J Cardiol 118, no. 8 (October 15, 2016): 1211–16. https://doi.org/10.1016/j.amjcard.2016.07.040.
Parikh KS, Coles A, Schulte PJ, Kraus WE, Fleg JL, Keteyian SJ, et al. Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION). Am J Cardiol. 2016 Oct 15;118(8):1211–6.
Parikh, Kishan S., et al. “Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).Am J Cardiol, vol. 118, no. 8, Oct. 2016, pp. 1211–16. Pubmed, doi:10.1016/j.amjcard.2016.07.040.
Parikh KS, Coles A, Schulte PJ, Kraus WE, Fleg JL, Keteyian SJ, Piña IL, Fiuzat M, Whellan DJ, O’Connor CM, Mentz RJ. Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION). Am J Cardiol. 2016 Oct 15;118(8):1211–1216.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

October 15, 2016

Volume

118

Issue

8

Start / End Page

1211 / 1216

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Quality of Life
  • Proportional Hazards Models
  • Prognosis
  • Oxygen Consumption
  • Mortality
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans