Skip to main content
Journal cover image

Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies.

Publication ,  Journal Article
Modena, BD; Milam, R; Harrison, F; Cheeseman, JA; Abecassis, MM; Friedewald, JJ; Kirk, AD; Salomon, DR
Published in: Am J Transplant
March 2017

An unbalanced microbiome may lead to disease by creating aberrant immune responses. A recent association of cellular rejection with the development of interstitial fibrosis and tubular atrophy (IFTA) suggests the role of immune-mediated tissue injury. We hypothesized that developing IFTA correlates with altered urinary tract microbiomes (UMBs). UMBs at two serial time points, 1 and 6-8 months posttransplant, were assessed by 16S microbial ribosomal gene sequencing in 25 patients developing biopsy-proven IFTA compared to 23 transplant patients with normal biopsies and excellent function (TX) and 20 healthy nontransplant controls (HC). Streptococcus, the dominant genera in HC males, was lower in IFTA and TX males at 1 month compared to HCs. At 6-8 months, Streptococcus was further decreased in IFTA males, but normalized in TX. IFTA males and females had increases in number of genera per sample at 6-8 months. UMB composition varied substantially between individuals in all groups. Despite the wide variation in UMBs between individuals, IFTA was associated with a loss in dominant resident urinary microbes in males, and a parallel increase in nonresident, pathogenic bacteria in males and females. UMB changes may contribute to IFTA development by alteration of the host immune response.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

March 2017

Volume

17

Issue

3

Start / End Page

712 / 723

Location

United States

Related Subject Headings

  • Surgery
  • Risk Factors
  • RNA, Ribosomal, 16S
  • Prognosis
  • Middle Aged
  • Microbiota
  • Male
  • Lung Diseases, Interstitial
  • Kidney Tubules
  • Kidney Transplantation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Modena, B. D., Milam, R., Harrison, F., Cheeseman, J. A., Abecassis, M. M., Friedewald, J. J., … Salomon, D. R. (2017). Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies. Am J Transplant, 17(3), 712–723. https://doi.org/10.1111/ajt.14038
Modena, B. D., R. Milam, F. Harrison, J. A. Cheeseman, M. M. Abecassis, J. J. Friedewald, A. D. Kirk, and D. R. Salomon. “Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies.Am J Transplant 17, no. 3 (March 2017): 712–23. https://doi.org/10.1111/ajt.14038.
Modena BD, Milam R, Harrison F, Cheeseman JA, Abecassis MM, Friedewald JJ, et al. Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies. Am J Transplant. 2017 Mar;17(3):712–23.
Modena, B. D., et al. “Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies.Am J Transplant, vol. 17, no. 3, Mar. 2017, pp. 712–23. Pubmed, doi:10.1111/ajt.14038.
Modena BD, Milam R, Harrison F, Cheeseman JA, Abecassis MM, Friedewald JJ, Kirk AD, Salomon DR. Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies. Am J Transplant. 2017 Mar;17(3):712–723.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

March 2017

Volume

17

Issue

3

Start / End Page

712 / 723

Location

United States

Related Subject Headings

  • Surgery
  • Risk Factors
  • RNA, Ribosomal, 16S
  • Prognosis
  • Middle Aged
  • Microbiota
  • Male
  • Lung Diseases, Interstitial
  • Kidney Tubules
  • Kidney Transplantation