Gene Editing: A New Tool for Viral Disease.

Published

Journal Article (Review)

The emergence of the CRISPR/Cas system of antiviral adaptive immunity in bacteria as a facile system for gene editing in mammalian cells may well lead to gene editing becoming a novel treatment for a range of human diseases, especially those caused by deleterious germline mutations. Another potential target for gene editing are DNA viruses that cause chronic pathogenic diseases that cannot be cured by using currently available drugs. We review the current state of this field and discuss the potential advantages and problems with using a gene editing approach as a treatment for diseases caused by DNA viruses.

Full Text

Duke Authors

Cited Authors

  • Kennedy, EM; Cullen, BR

Published Date

  • January 2017

Published In

Volume / Issue

  • 68 /

Start / End Page

  • 401 - 411

PubMed ID

  • 27576009

Pubmed Central ID

  • 27576009

Electronic International Standard Serial Number (EISSN)

  • 1545-326X

International Standard Serial Number (ISSN)

  • 0066-4219

Digital Object Identifier (DOI)

  • 10.1146/annurev-med-051215-031129

Language

  • eng