Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity.
Nuclear transport of immune receptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune activation. Whether and how this process is regulated at the level of the nuclear pore complex (NPC) remains unclear. Here, we report that CPR5, which plays a key inhibitory role in effector-triggered immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin. CPR5 associates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC. Consequently, these coordinated NPC actions result in simultaneous activation of diverse stress-related signaling pathways and constitute an essential regulatory mechanism specific for ETI/PCD induction.
Duke Scholars
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Related Subject Headings
- Signal Transduction
- Protein Conformation
- Nuclear Pore
- Membrane Proteins
- Gene Expression Regulation, Plant
- Developmental Biology
- Cell Cycle Proteins
- Arabidopsis Proteins
- Arabidopsis
- Active Transport, Cell Nucleus
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Signal Transduction
- Protein Conformation
- Nuclear Pore
- Membrane Proteins
- Gene Expression Regulation, Plant
- Developmental Biology
- Cell Cycle Proteins
- Arabidopsis Proteins
- Arabidopsis
- Active Transport, Cell Nucleus