Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity.

Published

Journal Article

Nuclear transport of immune receptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune activation. Whether and how this process is regulated at the level of the nuclear pore complex (NPC) remains unclear. Here, we report that CPR5, which plays a key inhibitory role in effector-triggered immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin. CPR5 associates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC. Consequently, these coordinated NPC actions result in simultaneous activation of diverse stress-related signaling pathways and constitute an essential regulatory mechanism specific for ETI/PCD induction.

Full Text

Duke Authors

Cited Authors

  • Gu, Y; Zebell, SG; Liang, Z; Wang, S; Kang, B-H; Dong, X

Published Date

  • September 2016

Published In

Volume / Issue

  • 166 / 6

Start / End Page

  • 1526 - 1538.e11

PubMed ID

  • 27569911

Pubmed Central ID

  • 27569911

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2016.07.042

Language

  • eng