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Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity.

Publication ,  Journal Article
Gu, Y; Zebell, SG; Liang, Z; Wang, S; Kang, B-H; Dong, X
Published in: Cell
September 2016

Nuclear transport of immune receptors, signal transducers, and transcription factors is an essential regulatory mechanism for immune activation. Whether and how this process is regulated at the level of the nuclear pore complex (NPC) remains unclear. Here, we report that CPR5, which plays a key inhibitory role in effector-triggered immunity (ETI) and programmed cell death (PCD) in plants, is a novel transmembrane nucleoporin. CPR5 associates with anchors of the NPC selective barrier to constrain nuclear access of signaling cargos and sequesters cyclin-dependent kinase inhibitors (CKIs) involved in ETI signal transduction. Upon activation by immunoreceptors, CPR5 undergoes an oligomer to monomer conformational switch, which coordinates CKI release for ETI signaling and reconfigures the selective barrier to allow significant influx of nuclear signaling cargos through the NPC. Consequently, these coordinated NPC actions result in simultaneous activation of diverse stress-related signaling pathways and constitute an essential regulatory mechanism specific for ETI/PCD induction.

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Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

September 2016

Volume

166

Issue

6

Start / End Page

1526 / 1538.e11

Related Subject Headings

  • Signal Transduction
  • Protein Conformation
  • Nuclear Pore
  • Membrane Proteins
  • Gene Expression Regulation, Plant
  • Developmental Biology
  • Cell Cycle Proteins
  • Arabidopsis Proteins
  • Arabidopsis
  • Active Transport, Cell Nucleus
 

Citation

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Gu, Y., Zebell, S. G., Liang, Z., Wang, S., Kang, B.-H., & Dong, X. (2016). Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. Cell, 166(6), 1526-1538.e11. https://doi.org/10.1016/j.cell.2016.07.042
Gu, Yangnan, Sophia G. Zebell, Zizhen Liang, Shui Wang, Byung-Ho Kang, and Xinnian Dong. “Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity.Cell 166, no. 6 (September 2016): 1526-1538.e11. https://doi.org/10.1016/j.cell.2016.07.042.
Gu Y, Zebell SG, Liang Z, Wang S, Kang B-H, Dong X. Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. Cell. 2016 Sep;166(6):1526-1538.e11.
Gu, Yangnan, et al. “Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity.Cell, vol. 166, no. 6, Sept. 2016, pp. 1526-1538.e11. Epmc, doi:10.1016/j.cell.2016.07.042.
Gu Y, Zebell SG, Liang Z, Wang S, Kang B-H, Dong X. Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity. Cell. 2016 Sep;166(6):1526-1538.e11.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

September 2016

Volume

166

Issue

6

Start / End Page

1526 / 1538.e11

Related Subject Headings

  • Signal Transduction
  • Protein Conformation
  • Nuclear Pore
  • Membrane Proteins
  • Gene Expression Regulation, Plant
  • Developmental Biology
  • Cell Cycle Proteins
  • Arabidopsis Proteins
  • Arabidopsis
  • Active Transport, Cell Nucleus