NCCN Guidelines Insights: Non-Hodgkin's Lymphomas, Version 3.2016.

Journal Article (Journal Article)

Peripheral T-cell lymphomas (PTCLs) represent a relatively uncommon heterogeneous group of non-Hodgkin's lymphomas (NHLs) with an aggressive clinical course and poor prognosis. Anthracycline-based multiagent chemotherapy with or without radiation therapy followed by first-line consolidation with high-dose therapy followed by autologous stem cell rescue (HDT/ASCR) is the standard approach to most of the patients with newly diagnosed PTCL. Relapsed or refractory disease is managed with second-line systemic therapy followed by HDT/ASCR or allogeneic stem cell transplant, based on the patient's eligibility for transplant. In recent years, several newer agents have shown significant activity in patients with relapsed or refractory disease across all 4 subtypes of PTCL. These NCCN Guideline Insights highlight the important updates to the NCCN Guidelines for NHL, specific to the management of patients with relapsed or refractory PTCL.

Full Text

Duke Authors

Cited Authors

  • Horwitz, SM; Zelenetz, AD; Gordon, LI; Wierda, WG; Abramson, JS; Advani, RH; Andreadis, CB; Bartlett, N; Byrd, JC; Fayad, LE; Fisher, RI; Glenn, MJ; Habermann, TM; Lee Harris, N; Hernandez-Ilizaliturri, F; Hoppe, RT; Kaminski, MS; Kelsey, CR; Kim, YH; Krivacic, S; LaCasce, AS; Lunning, M; Nademanee, A; Press, O; Rabinovitch, R; Reddy, N; Reid, E; Roberts, K; Saad, AA; Sokol, L; Swinnen, LJ; Vose, JM; Yahalom, J; Zafar, N; Dwyer, M; Sundar, H; Porcu, P

Published Date

  • September 2016

Published In

Volume / Issue

  • 14 / 9

Start / End Page

  • 1067 - 1079

PubMed ID

  • 27587620

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2016.0117


  • eng

Conference Location

  • United States