Proprotein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies for Acute Coronary Syndrome: A Narrative Review.
Published
Journal Article (Review)
Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) are an emerging therapy for dyslipidemia. Acute coronary events induce a dynamic increase of PCSK9 levels that may play a role in plaque vulnerability of both culprit and nonculprit coronary vessels. Growing evidence highlights a potential key role of PCSK9 antibodies in managing acute coronary syndrome. This review describes the influence of PCSK9 antibodies on plaque composition and instability, as well as the pharmacokinetic profile and the potential anti-inflammatory and antithrombotic mechanisms associated with PCSK9 inhibition that may confer benefits during the early phase of acute coronary syndrome. The authors posit a rationale for the use of PCSK9 antibodies in patients with acute coronary syndrome and highlight the need for further investigation in this area.
Full Text
Duke Authors
Cited Authors
- Navarese, EP; Kolodziejczak, M; Kereiakes, DJ; Tantry, US; O'Connor, C; Gurbel, PA
Published Date
- May 3, 2016
Published In
Volume / Issue
- 164 / 9
Start / End Page
- 600 - 607
PubMed ID
- 26999484
Pubmed Central ID
- 26999484
Electronic International Standard Serial Number (EISSN)
- 1539-3704
Digital Object Identifier (DOI)
- 10.7326/M15-2994
Language
- eng
Conference Location
- United States