Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production.

Journal Article (Journal Article)

This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum beta-lactams despite constitutive production of high levels of beta-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.

Full Text

Duke Authors

Cited Authors

  • Mellencamp, MA; Roccaforte, JS; Preheim, LC; Sanders, CC; Anene, CA; Bittner, MJ

Published Date

  • November 1990

Published In

Volume / Issue

  • 9 / 11

Start / End Page

  • 827 - 830

PubMed ID

  • 2086219

International Standard Serial Number (ISSN)

  • 0934-9723

Digital Object Identifier (DOI)

  • 10.1007/BF01967384


  • eng

Conference Location

  • Germany