Spatial Measures of Genetic Heterogeneity During Carcinogenesis.
Journal Article (Journal Article)
In this work we explore the temporal dynamics of spatial heterogeneity during the process of tumorigenesis from healthy tissue. We utilize a spatial stochastic model of mutation accumulation and clonal expansion in a structured tissue to describe this process. Under a two-step tumorigenesis model, we first derive estimates of a non-spatial measure of diversity: Simpson's Index, which is the probability that two individuals sampled at random from the population are identical, in the premalignant population. We next analyze two new measures of spatial population heterogeneity. In particular we study the typical length scale of genetic heterogeneity during the carcinogenesis process and estimate the extent of a surrounding premalignant clone given a clinical observation of a premalignant point biopsy. This evolutionary framework contributes to a growing literature focused on developing a better understanding of the spatial population dynamics of cancer initiation and progression.
Full Text
Duke Authors
Cited Authors
- Storey, K; Ryser, MD; Leder, K; Foo, J
Published Date
- February 2017
Published In
Volume / Issue
- 79 / 2
Start / End Page
- 237 - 276
PubMed ID
- 27905065
Pubmed Central ID
- PMC6065111
Electronic International Standard Serial Number (EISSN)
- 1522-9602
Digital Object Identifier (DOI)
- 10.1007/s11538-016-0234-5
Language
- eng
Conference Location
- United States