Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: This article reviews recently identified genomic mutations in prostate cancer. RECENT FINDINGS: Advanced sequencing technologies have made it possible to obtain large amounts of data on genomes and transcriptomes of cancers. Such technologies have been used to sequence prostate cancer of different stages, from treatment-naive cancers, to advanced, castration-resistant cancers to the aggressive small cell neuroendocrine carcinomas. For each category of prostate cancer, distinct and overlapping DNA sequence alterations were discovered, including point mutations, small insertions or deletions, copy number changes and chromosomal rearrangements. There appears to be a stepwise increase in genomic alterations from low risk to high risk to advanced cancers. SUMMARY: These novel findings have significantly increased our knowledge of the genetic basis of human prostate cancer and the molecular mechanisms responsible for disease progression and treatment resistance. Some of the lesions are potential therapeutic targets. Studies along this direction will eventually make it possible to design personalized management plans for individual patients.

Full Text

Duke Authors

Cited Authors

  • Huang, J; Wang, JK; Sun, Y

Published Date

  • May 2013

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 189 - 193

PubMed ID

  • 23385974

Pubmed Central ID

  • PMC4086526

Electronic International Standard Serial Number (EISSN)

  • 1473-6586

Digital Object Identifier (DOI)

  • 10.1097/MOU.0b013e32835e9ef4


  • eng

Conference Location

  • United States