The molecular basis for ethnic variation and histological subtype differences in prostate cancer.

Journal Article (Journal Article;Review)

Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. These surging data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. In this review, differences in the incidence of prostate cancer and the prevalence of main genetic alterations between Asian and Western populations are discussed. We also review the recent findings on the mechanisms underlying neuroendocrine differentiation of prostate cancer and the development of small cell neuroendocrine carcinoma after androgen deprivation therapy.

Full Text

Duke Authors

Cited Authors

  • Zong, Y; Goldstein, AS; Huang, J

Published Date

  • September 2013

Published In

Volume / Issue

  • 56 / 9

Start / End Page

  • 780 - 787

PubMed ID

  • 23852643

Pubmed Central ID

  • PMC4078990

Electronic International Standard Serial Number (EISSN)

  • 1869-1889

Digital Object Identifier (DOI)

  • 10.1007/s11427-013-4522-0

Language

  • eng

Conference Location

  • China