α-Helical coiled-coil peptide materials for biomedical applications.

Published

Journal Article (Review)

Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combinations of these. Currently these materials are being developed for a range of biotechnological and medical applications, including drug delivery systems for controlled release, targeted nanomaterials, 'drug-free' therapeutics, vaccine delivery systems, and others. WIREs Nanomed Nanobiotechnol 2017, 9:e1424. doi: 10.1002/wnan.1424 For further resources related to this article, please visit the WIREs website.

Full Text

Duke Authors

Cited Authors

  • Wu, Y; Collier, JH

Published Date

  • March 2017

Published In

Volume / Issue

  • 9 / 2

PubMed ID

  • 27597649

Pubmed Central ID

  • 27597649

Electronic International Standard Serial Number (EISSN)

  • 1939-0041

International Standard Serial Number (ISSN)

  • 1939-5116

Digital Object Identifier (DOI)

  • 10.1002/wnan.1424

Language

  • eng