Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.
Publication
, Journal Article
Hu, J; Lan, T; Sun, Y; Chen, H; Yao, J; Rao, Y
Published in: Chemical communications (Cambridge, England)
October 2015
A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp(3))-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in the reaction. This new reaction demonstrates good reactivity and broad functional group tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chemicals via known transformations. Based on experimental and theoretical studies, a mechanism involving the Pd(II)/(IV) pathway is proposed for this hydroxylation reaction.
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Published In
Chemical communications (Cambridge, England)
DOI
EISSN
1364-548X
ISSN
1359-7345
Publication Date
October 2015
Volume
51
Issue
80
Start / End Page
14929 / 14932
Related Subject Headings
- Water
- Palladium
- Oxygen
- Organic Chemistry
- Hydroxylation
- Catalysis
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Hu, J., Lan, T., Sun, Y., Chen, H., Yao, J., & Rao, Y. (2015). Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source. Chemical Communications (Cambridge, England), 51(80), 14929–14932. https://doi.org/10.1039/c5cc04952k
Hu, Jiantao, Tianlong Lan, Yihua Sun, Hui Chen, Jiannian Yao, and Yu Rao. “Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.” Chemical Communications (Cambridge, England) 51, no. 80 (October 2015): 14929–32. https://doi.org/10.1039/c5cc04952k.
Hu J, Lan T, Sun Y, Chen H, Yao J, Rao Y. Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source. Chemical communications (Cambridge, England). 2015 Oct;51(80):14929–32.
Hu, Jiantao, et al. “Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.” Chemical Communications (Cambridge, England), vol. 51, no. 80, Oct. 2015, pp. 14929–32. Epmc, doi:10.1039/c5cc04952k.
Hu J, Lan T, Sun Y, Chen H, Yao J, Rao Y. Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source. Chemical communications (Cambridge, England). 2015 Oct;51(80):14929–14932.
Published In
Chemical communications (Cambridge, England)
DOI
EISSN
1364-548X
ISSN
1359-7345
Publication Date
October 2015
Volume
51
Issue
80
Start / End Page
14929 / 14932
Related Subject Headings
- Water
- Palladium
- Oxygen
- Organic Chemistry
- Hydroxylation
- Catalysis
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences