Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth.
Journal Article (Journal Article)
Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth. To reduce tissue scattering, we propose to use glycerol as an optical clearing agent in OR-PAM. Our results show that the imaging performance of OR-PAM can be greatly enhanced by optical clearing both in vitro and in vivo.
- Zhou, Y; Yao, J; Wang, LV
- July 2013
Volume / Issue
- 38 / 14
Start / End Page
- 2592 - 2595
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)