Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth.

Journal Article (Journal Article)

Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth. To reduce tissue scattering, we propose to use glycerol as an optical clearing agent in OR-PAM. Our results show that the imaging performance of OR-PAM can be greatly enhanced by optical clearing both in vitro and in vivo.

Full Text

Published version (via Digital Object Identifier)
Pubmed Central version

Duke Authors

Yao, Junjie

Cited Authors

Zhou, Y; Yao, J; Wang, LV

Published Date

July 2013

Published In

Optics Letters

Volume / Issue

38 / 14

Start / End Page

2592 - 2595

PubMed ID

23939121

Pubmed Central ID

PMC3759812

Electronic International Standard Serial Number (EISSN)

1539-4794

International Standard Serial Number (ISSN)

0146-9592

Digital Object Identifier (DOI)

10.1364/ol.38.002592

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