Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth.

Journal Article (Journal Article)

Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth. To reduce tissue scattering, we propose to use glycerol as an optical clearing agent in OR-PAM. Our results show that the imaging performance of OR-PAM can be greatly enhanced by optical clearing both in vitro and in vivo.

Full Text

Duke Authors

Cited Authors

  • Zhou, Y; Yao, J; Wang, LV

Published Date

  • July 2013

Published In

Volume / Issue

  • 38 / 14

Start / End Page

  • 2592 - 2595

PubMed ID

  • 23939121

Pubmed Central ID

  • PMC3759812

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.38.002592


  • eng