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Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo.

Publication ,  Journal Article
Yao, J; Xia, J; Maslov, KI; Nasiriavanaki, M; Tsytsarev, V; Demchenko, AV; Wang, LV
Published in: NeuroImage
January 2013

We have demonstrated the feasibility of imaging mouse brain metabolism using photoacoustic computed tomography (PACT), a fast, noninvasive and functional imaging modality with optical contrast and acoustic resolution. Brain responses to forepaw stimulations were imaged transdermally and transcranially. 2-NBDG, which diffuses well across the blood-brain-barrier, provided exogenous contrast for photoacoustic imaging of glucose response. Concurrently, hemoglobin provided endogenous contrast for photoacoustic imaging of hemodynamic response. Glucose and hemodynamic responses were quantitatively decoupled by using two-wavelength measurements. We found that glucose uptake and blood perfusion around the somatosensory region of the contralateral hemisphere were both increased by stimulations, indicating elevated neuron activity. While the glucose response area was more homogenous and confined within the somatosensory region, the hemodynamic response area had a clear vascular pattern and spread wider than the somatosensory region. Our results demonstrate that 2-NBDG-enhanced PACT is a promising tool for noninvasive studies of brain metabolism.

Duke Scholars

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Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

January 2013

Volume

64

Start / End Page

257 / 266

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tissue Distribution
  • Somatosensory Cortex
  • Photoacoustic Techniques
  • Neurology & Neurosurgery
  • Mice
  • Glucose
  • Female
  • Elasticity Imaging Techniques
  • Deoxyglucose
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yao, J., Xia, J., Maslov, K. I., Nasiriavanaki, M., Tsytsarev, V., Demchenko, A. V., & Wang, L. V. (2013). Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo. NeuroImage, 64, 257–266. https://doi.org/10.1016/j.neuroimage.2012.08.054
Yao, Junjie, Jun Xia, Konstantin I. Maslov, Mohammadreza Nasiriavanaki, Vassiliy Tsytsarev, Alexei V. Demchenko, and Lihong V. Wang. “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo.NeuroImage 64 (January 2013): 257–66. https://doi.org/10.1016/j.neuroimage.2012.08.054.
Yao J, Xia J, Maslov KI, Nasiriavanaki M, Tsytsarev V, Demchenko AV, et al. Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo. NeuroImage. 2013 Jan;64:257–66.
Yao, Junjie, et al. “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo.NeuroImage, vol. 64, Jan. 2013, pp. 257–66. Epmc, doi:10.1016/j.neuroimage.2012.08.054.
Yao J, Xia J, Maslov KI, Nasiriavanaki M, Tsytsarev V, Demchenko AV, Wang LV. Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo. NeuroImage. 2013 Jan;64:257–266.
Journal cover image

Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

January 2013

Volume

64

Start / End Page

257 / 266

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tissue Distribution
  • Somatosensory Cortex
  • Photoacoustic Techniques
  • Neurology & Neurosurgery
  • Mice
  • Glucose
  • Female
  • Elasticity Imaging Techniques
  • Deoxyglucose