Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo.

Journal Article (Journal Article)

At present, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures that provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high-resolution images, but also is safe for clinical use and broadly applicable. However, for soft tissue imaging, its mechanical wave-based image contrast fundamentally limits its ability to provide physiologically specific functional information. By contrast, photoacoustic endoscopy possesses a unique combination of functional optical contrast and high spatial resolution at clinically relevant depths, ideal for imaging soft tissues. With these attributes, photoacoustic endoscopy can overcome the current limitations of ultrasound endoscopy. Moreover, the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; photoacoustic endoscopy systems are inherently compatible with ultrasound imaging, thereby enabling multimodality imaging with complementary contrast. Here we present simultaneous photoacoustic and ultrasonic dual-mode endoscopy and show its ability to image internal organs in vivo, thus illustrating its potential clinical application.

Full Text

Duke Authors

Cited Authors

  • Yang, J-M; Favazza, C; Chen, R; Yao, J; Cai, X; Maslov, K; Zhou, Q; Shung, KK; Wang, LV

Published Date

  • August 2012

Published In

Volume / Issue

  • 18 / 8

Start / End Page

  • 1297 - 1302

PubMed ID

  • 22797808

Pubmed Central ID

  • PMC3885361

Electronic International Standard Serial Number (EISSN)

  • 1546-170X

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm.2823


  • eng