Functional photoacoustic microscopy of pH.

Journal Article (letter)

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

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Duke Authors

Yao, Junjie

Cited Authors

Chatni, MR; Yao, J; Danielli, A; Favazza, CP; Maslov, KI; Wang, LV

Published Date

October 2011

Published In

Journal of Biomedical Optics

Volume / Issue

16 / 10

Start / End Page

100503 -

PubMed ID

22029342

Pubmed Central ID

22029342

Electronic International Standard Serial Number (EISSN)

1560-2281

International Standard Serial Number (ISSN)

1083-3668

Digital Object Identifier (DOI)

10.1117/1.3644495

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