Functional photoacoustic microscopy of pH.

Journal Article (letter;Journal Article)

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

Full Text

Duke Authors

Cited Authors

  • Chatni, MR; Yao, J; Danielli, A; Favazza, CP; Maslov, KI; Wang, LV

Published Date

  • October 2011

Published In

Volume / Issue

  • 16 / 10

Start / End Page

  • 100503 -

PubMed ID

  • 22029342

Pubmed Central ID

  • PMC3210191

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.3644495

Language

  • eng