Functional photoacoustic microscopy of pH.
Journal Article (letter)
pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.
Full Text
Duke Authors
Cited Authors
- Chatni, MR; Yao, J; Danielli, A; Favazza, CP; Maslov, KI; Wang, LV
Published Date
- October 2011
Published In
Volume / Issue
- 16 / 10
Start / End Page
- 100503 -
PubMed ID
- 22029342
Pubmed Central ID
- 22029342
Electronic International Standard Serial Number (EISSN)
- 1560-2281
International Standard Serial Number (ISSN)
- 1083-3668
Digital Object Identifier (DOI)
- 10.1117/1.3644495
Language
- eng