In vivo imaging of epileptic activity using 2-NBDG, a fluorescent deoxyglucose analog.


Journal Article

Accurately locating epileptic foci has great importance in advancing the treatment of epilepsy. In this study, epileptic seizures were first induced by intracortical injection of 4-aminopyridine in rats. A fluorescent deoxyglucose substitute, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG), was then continuously injected via the tail vein. Brain glucose metabolism was subsequently monitored by fluorescence imaging of 2-NBDG. The initial uptake rate of 2-NBDG at the injection site of 4-aminopyridine significantly exceeded that of the control injection site, which indicated local hypermetabolism induced by seizures. Our results show that 2-NBDG can be used for localizing epileptic foci.

Full Text

Duke Authors

Cited Authors

  • Tsytsarev, V; Maslov, KI; Yao, J; Parameswar, AR; Demchenko, AV; Wang, LV

Published Date

  • January 2012

Published In

Volume / Issue

  • 203 / 1

Start / End Page

  • 136 - 140

PubMed ID

  • 21939688

Pubmed Central ID

  • 21939688

Electronic International Standard Serial Number (EISSN)

  • 1872-678X

International Standard Serial Number (ISSN)

  • 0165-0270

Digital Object Identifier (DOI)

  • 10.1016/j.jneumeth.2011.09.005


  • eng