In vivo imaging of epileptic activity using 2-NBDG, a fluorescent deoxyglucose analog.

Published

Journal Article

Accurately locating epileptic foci has great importance in advancing the treatment of epilepsy. In this study, epileptic seizures were first induced by intracortical injection of 4-aminopyridine in rats. A fluorescent deoxyglucose substitute, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG), was then continuously injected via the tail vein. Brain glucose metabolism was subsequently monitored by fluorescence imaging of 2-NBDG. The initial uptake rate of 2-NBDG at the injection site of 4-aminopyridine significantly exceeded that of the control injection site, which indicated local hypermetabolism induced by seizures. Our results show that 2-NBDG can be used for localizing epileptic foci.

Full Text

Duke Authors

Cited Authors

  • Tsytsarev, V; Maslov, KI; Yao, J; Parameswar, AR; Demchenko, AV; Wang, LV

Published Date

  • January 2012

Published In

Volume / Issue

  • 203 / 1

Start / End Page

  • 136 - 140

PubMed ID

  • 21939688

Pubmed Central ID

  • 21939688

Electronic International Standard Serial Number (EISSN)

  • 1872-678X

International Standard Serial Number (ISSN)

  • 0165-0270

Digital Object Identifier (DOI)

  • 10.1016/j.jneumeth.2011.09.005

Language

  • eng