Photoacoustic tomography: fundamentals, advances and prospects.

Journal Article (Review;Journal Article)

Optical microscopy has been contributing to the development of life science for more than three centuries. However, due to strong optical scattering in tissue, its in vivo imaging ability has been restricted to studies at superficial depths. Advances in photoacoustic tomography (PAT) now allow multiscale imaging at depths from sub-millimeter to several centimeters, with spatial resolutions from sub-micrometer to sub-millimeter. Because of this high scalability and its unique optical absorption contrast, PAT is capable of performing anatomical, functional, molecular and fluid-dynamic imaging at various system levels, and is playing an increasingly important role in fundamental biological research and clinical practice. This review discusses recent technical progress in PAT and presents corresponding applications. It ends with a discussion of several prospects and their technical challenges.

Full Text

Duke Authors

Cited Authors

  • Yao, J; Wang, LV

Published Date

  • September 2011

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 332 - 345

PubMed ID

  • 22025335

Pubmed Central ID

  • PMC3205414

Electronic International Standard Serial Number (EISSN)

  • 1555-4317

International Standard Serial Number (ISSN)

  • 1555-4309

Digital Object Identifier (DOI)

  • 10.1002/cmmi.443


  • eng