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Photoacoustic microscopy of microvascular responses to cortical electrical stimulation.

Publication ,  Journal Article
Tsytsarev, V; Hu, S; Yao, J; Maslov, K; Barbour, DL; Wang, LV
Published in: Journal of biomedical optics
July 2011

Advances in the functional imaging of cortical hemodynamics have greatly facilitated the understanding of neurovascular coupling. In this study, label-free optical-resolution photoacoustic microscopy (OR-PAM) was used to monitor microvascular responses to direct electrical stimulations of the mouse somatosensory cortex through a cranial opening. The responses appeared in two forms: vasoconstriction and vasodilatation. The transition between these two forms of response was observed in single vessels by varying the stimulation intensity. Marked correlation was found between the current-dependent responses of two daughter vessels bifurcating from the same parent vessel. Statistical analysis of twenty-seven vessels from three different animals further characterized the spatial-temporal features and the current dependence of the microvascular response. Our results demonstrate that OR-PAM is a valuable tool to study neurovascular coupling at the microscopic level.

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Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

July 2011

Volume

16

Issue

7

Start / End Page

076002

Related Subject Headings

  • Vasodilation
  • Vasoconstriction
  • Somatosensory Cortex
  • Optics
  • Optical Phenomena
  • Microvessels
  • Microscopy, Acoustic
  • Mice
  • Lasers, Solid-State
  • Electric Stimulation
 

Citation

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Tsytsarev, V., Hu, S., Yao, J., Maslov, K., Barbour, D. L., & Wang, L. V. (2011). Photoacoustic microscopy of microvascular responses to cortical electrical stimulation. Journal of Biomedical Optics, 16(7), 076002. https://doi.org/10.1117/1.3594785
Tsytsarev, Vassiliy, Song Hu, Junjie Yao, Konstantin Maslov, Dennis L. Barbour, and Lihong V. Wang. “Photoacoustic microscopy of microvascular responses to cortical electrical stimulation.Journal of Biomedical Optics 16, no. 7 (July 2011): 076002. https://doi.org/10.1117/1.3594785.
Tsytsarev V, Hu S, Yao J, Maslov K, Barbour DL, Wang LV. Photoacoustic microscopy of microvascular responses to cortical electrical stimulation. Journal of biomedical optics. 2011 Jul;16(7):076002.
Tsytsarev, Vassiliy, et al. “Photoacoustic microscopy of microvascular responses to cortical electrical stimulation.Journal of Biomedical Optics, vol. 16, no. 7, July 2011, p. 076002. Epmc, doi:10.1117/1.3594785.
Tsytsarev V, Hu S, Yao J, Maslov K, Barbour DL, Wang LV. Photoacoustic microscopy of microvascular responses to cortical electrical stimulation. Journal of biomedical optics. 2011 Jul;16(7):076002.

Published In

Journal of biomedical optics

DOI

EISSN

1560-2281

ISSN

1083-3668

Publication Date

July 2011

Volume

16

Issue

7

Start / End Page

076002

Related Subject Headings

  • Vasodilation
  • Vasoconstriction
  • Somatosensory Cortex
  • Optics
  • Optical Phenomena
  • Microvessels
  • Microscopy, Acoustic
  • Mice
  • Lasers, Solid-State
  • Electric Stimulation