Photoacoustic elastography.

Journal Article (Journal Article)

Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoacoustic computed tomography system. The feasibility of photoacoustic elastography was first demonstrated by imaging the strains of single-layer and bilayer gelatin phantoms with various stiffness values. The measured strains agreed well with theoretical values, with an average error of less than 5.2%. Next, in vivo photoacoustic elastography was demonstrated on a mouse leg, where the fat and muscle distribution was mapped based on the elasticity contrast. We confirmed the photoacoustic elastography results by ultrasound elastography performed simultaneously.

Full Text

Duke Authors

Cited Authors

  • Hai, P; Yao, J; Li, G; Li, C; Wang, LV

Published Date

  • February 2016

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 725 - 728

PubMed ID

  • 26872173

Pubmed Central ID

  • PMC4858317

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.41.000725


  • eng