In vivo photoacoustic tomography of myoglobin oxygen saturation.

Journal Article (Journal Article)

Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb ). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.

Full Text

Duke Authors

Cited Authors

  • Lin, L; Yao, J; Li, L; Wang, LV

Published Date

  • June 2016

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 61002 -

PubMed ID

  • 26719943

Pubmed Central ID

  • PMC5397140

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.jbo.21.6.061002

Language

  • eng