In vivo photoacoustic tomography of myoglobin oxygen saturation.
Journal Article (Journal Article)
Myoglobin is an essential oxygen-binding hemoprotein in skeletal and cardiac muscles that buffers intracellular oxygen (O2) concentration in response to hypoxia or elevated muscle activities. We present a method that uses photoacoustic computed tomography to measure the distribution of myoglobin in tissue and the oxygen saturation of myoglobin (sO2-Mb ). From photoacoustic measurements of mice in different oxygenation states, we performed calibration-free quantification of the sO2-Mb change in the backbone muscle in vivo.
Full Text
Duke Authors
Cited Authors
- Lin, L; Yao, J; Li, L; Wang, LV
Published Date
- June 2016
Published In
Volume / Issue
- 21 / 6
Start / End Page
- 61002 -
PubMed ID
- 26719943
Pubmed Central ID
- PMC5397140
Electronic International Standard Serial Number (EISSN)
- 1560-2281
International Standard Serial Number (ISSN)
- 1083-3668
Digital Object Identifier (DOI)
- 10.1117/1.jbo.21.6.061002
Language
- eng