Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media.
Journal Article
We propose a calibration-free photoacoustic (PA) method for transverse flow measurements. In this method, a pulsed periodically structured (i.e., grating patterned) optical beam is used to illuminate flowing absorptive particles in an optically scattering medium. The PA signal amplitudes measured over consecutive laser pulses carry an imprint of the illumination structure. The modulation frequency of the imprint is proportional to the component of the flow speed projected onto the normal axis of the striped illumination pattern. This method can tolerate high particle density, and is insensitive to the particle size, thus calibration-free. Bovine blood and microsphere phantoms were used to validate the proposed method. Blood flow in a mouse ear was measured in vivo as well.
Full Text
Duke Authors
Cited Authors
- Yao, J; Gilson, RC; Maslov, KI; Wang, L; Wang, LV
Published Date
- April 2014
Published In
Volume / Issue
- 19 / 4
Start / End Page
- 046007 -
PubMed ID
- 24718385
Pubmed Central ID
- 24718385
Electronic International Standard Serial Number (EISSN)
- 1560-2281
International Standard Serial Number (ISSN)
- 1083-3668
Digital Object Identifier (DOI)
- 10.1117/1.jbo.19.4.046007
Language
- eng