Ultrasound-heated photoacoustic flowmetry.

Journal Article (Journal Article)

We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. Photoacoustic flowmetry in a continuous medium remains a challenge in the optical diffusive regime. Here, both the HIFU heating and photoacoustic detection can focus at depths beyond the optical diffusion limit (~1 mm in soft tissue). This method can be applied to a continuous medium, i.e., a medium without discrete scatterers or absorbers resolvable by photoacoustic imaging. Flow speeds up to 41 mm·s-1 have been experimentally measured in a blood phantom covered by 1.5-mm-thick tissue.

Full Text

Duke Authors

Cited Authors

  • Wang, L; Yao, J; Maslov, KI; Xing, W; Wang, LV

Published Date

  • November 2013

Published In

Volume / Issue

  • 18 / 11

Start / End Page

  • 117003 -

PubMed ID

  • 24194064

Pubmed Central ID

  • PMC4030689

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.jbo.18.11.117003


  • eng