Invasive and transcranial photoacoustic imaging of the vascular response to brain electrical stimulation


Conference Paper

Advances in the brain functional imaging greatly facilitated the understanding of neurovascular coupling. For monitoring of the microvascular response to the brain electrical stimulation in vivo we used optical-resolution photoacoustic microscopy (OR-PAM) through the cranial openings as well as transcranially. Both types of the vascular response, vasoconstriction and vasodilatation, were clearly observed with good spatial and temporal resolution. Obtained results confirm one of the primary points of the neurovascular coupling theory that blood vessels could present vasoconstriction or vasodilatation in response to electrical stimulation, depending on the balance between inhibition and excitation of the different parts of the elements of the neurovascular coupling system. © 2010 Copyright SPIE - The International Society for Optical Engineering.

Full Text

Duke Authors

Cited Authors

  • Tsytsarev, V; Yao, J; Hu, S; Li, L; Favazza, CP; Maslov, KI; Wang, LV

Published Date

  • May 3, 2010

Published In

Volume / Issue

  • 7564 /

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9780819479600

Digital Object Identifier (DOI)

  • 10.1117/12.840290

Citation Source

  • Scopus