Noninvasive quantification of metabolic rate of oxygen (MRO2) by photoacoustic microscopy


Conference Paper

Many diseases, normal decay and physiological functions are closely related to alterations in the metabolic rate of oxygen (MRO2). In this study, we demonstrate that all the parameters for MRO2 quantification can be simultaneously obtained by optical-resolution photoacoustic microscopy (OR-PAM). MRO2 of the mouse ear under normothermia (31 °C skin temperature) and controlled systematic hyperthermia (42 °C skin temperature) was studied. As a result of hyperthermia, the MRO2 increased by 34.1%. The tumor hypermetabolism was also demonstrated by longitudinally monitoring a melanoma growing on a mouse ear. The results show that OR-PAM, as a single noninvasive imaging modality, is well suited for quantitative MRO 2 measurement in microenvironments. © 2011 SPIE.

Full Text

Duke Authors

Cited Authors

  • Yao, J; Maslov, KI; Wang, LV

Published Date

  • May 5, 2011

Published In

Volume / Issue

  • 7899 /

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9780819484369

Digital Object Identifier (DOI)

  • 10.1117/12.874777

Citation Source

  • Scopus