Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model


Conference Paper

A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance. © 2010 Copyright SPIE - The International Society for Optical Engineering.

Full Text

Duke Authors

Cited Authors

  • Hu, S; Oladipupo, S; Yao, J; Santeford, AC; Maslov, K; Kovalski, J; Arbeit, JM; Wang, LV

Published Date

  • May 3, 2010

Published In

Volume / Issue

  • 7564 /

International Standard Serial Number (ISSN)

  • 1605-7422

International Standard Book Number 13 (ISBN-13)

  • 9780819479600

Digital Object Identifier (DOI)

  • 10.1117/12.841177

Citation Source

  • Scopus