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A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds.

Publication ,  Journal Article
Priester, A; Natarajan, S; Le, JD; Garritano, J; Radosavcev, B; Grundfest, W; Margolis, DJ; Marks, LS; Huang, J
Published in: Am J Clin Exp Urol
2014

We have developed a system for evaluating magnetic resonance imaging of prostate cancer, using patient-specific 3D printed molds to facilitate MR-histology correlation. Prior to radical prostatectomy a patient receives a multiparametric MRI, which an expert genitourinary radiologist uses to identify and contour regions suspicious for disease. The same MR series is used to generate a prostate contour, which is the basis for design of a patient-specific mold. The 3D printed mold contains a series of evenly spaced parallel slits, each of which corresponds to a known MRI slice. After surgery, the patient's specimen is enclosed within the mold, and all whole-mount levels are obtained simultaneously through use of a multi-bladed slicing device. The levels are then formalin fixed, processed, and delivered to an expert pathologist, who identifies and grades all lesions within the slides. Finally, the lesion contours are loaded into custom software, which elastically warps them to fit the MR prostate contour. The suspicious regions on MR can then be directly compared to lesions on histology. Furthermore, the false-negative and false-positive regions on MR can be retrospectively examined, with the ultimate goal of developing methods for improving the predictive accuracy of MRI. This work presents the details of our analysis method, following a patient from diagnosis through the MR-histology correlation process. For this patient MRI successfully predicted the presence of cancer, but true lesion volume and extent were underestimated. Most cancer-positive regions missed on MR were observed to have patterns of low T2 signal, suggesting that there is potential to improve sensitivity.

Duke Scholars

Published In

Am J Clin Exp Urol

ISSN

2330-1910

Publication Date

2014

Volume

2

Issue

2

Start / End Page

127 / 135

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Priester, A., Natarajan, S., Le, J. D., Garritano, J., Radosavcev, B., Grundfest, W., … Huang, J. (2014). A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds. Am J Clin Exp Urol, 2(2), 127–135.
Priester, Alan, Shyam Natarajan, Jesse D. Le, James Garritano, Bryan Radosavcev, Warren Grundfest, Daniel Ja Margolis, Leonard S. Marks, and Jiaoti Huang. “A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds.Am J Clin Exp Urol 2, no. 2 (2014): 127–35.
Priester A, Natarajan S, Le JD, Garritano J, Radosavcev B, Grundfest W, et al. A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds. Am J Clin Exp Urol. 2014;2(2):127–35.
Priester, Alan, et al. “A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds.Am J Clin Exp Urol, vol. 2, no. 2, 2014, pp. 127–35.
Priester A, Natarajan S, Le JD, Garritano J, Radosavcev B, Grundfest W, Margolis DJ, Marks LS, Huang J. A system for evaluating magnetic resonance imaging of prostate cancer using patient-specific 3D printed molds. Am J Clin Exp Urol. 2014;2(2):127–135.

Published In

Am J Clin Exp Urol

ISSN

2330-1910

Publication Date

2014

Volume

2

Issue

2

Start / End Page

127 / 135

Location

United States