Prevalence of 16S rRNA methylase genes in Enterobacteriaceae isolates from a Greek university hospital.


Journal Article

16S ribosomal RNA methylase-mediated high-level resistance to 4-,6-aminoglycosides has been reported in clinical isolates of gram-negative bacilli from several countries. Three of 1534 (0.2%) isolates of Klebsiella pneumoniae and three of 734 (0.4%) Proteus mirabilis isolates from a university hospital in Athens, Greece, were positive for rmtB and highly resistant to all aminoglycosides tested (MICs ≥256 mg/L). Two of the K. pneumoniae rmtB-bearing isolates, were KPC-2 and OXA-10 producers and the third was a DHA-1 producer. One of the P. mirabilis isolates was a VIM-1 and OXA-10 producer and one was an OXA-10 producer. All rmtB-harbouring isolates were clonally unrelated. None of the E. coli (n = 1398) and Enterobacter spp. (n = 414) isolates were positive for armA, rmtA, rmtB, rmtC or rmtD.

Full Text

Cited Authors

  • Galani, I; Souli, M; Panagea, T; Poulakou, G; Kanellakopoulou, K; Giamarellou, H

Published Date

  • March 2012

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • E52 - E54

PubMed ID

  • 22264302

Pubmed Central ID

  • 22264302

Electronic International Standard Serial Number (EISSN)

  • 1469-0691

International Standard Serial Number (ISSN)

  • 1198-743X

Digital Object Identifier (DOI)

  • 10.1111/j.1469-0691.2011.03738.x


  • eng