In vitro interactions of antimicrobial combinations with fosfomycin against KPC-2-producing Klebsiella pneumoniae and protection of resistance development.


Journal Article

Using time-kill methodology, we investigated the interactions of fosfomycin with meropenem or colistin or gentamicin against 17 genetically distinct Klebsiella pneumoniae clinical isolates carrying blaKPC-2. Synergy was observed with meropenem or colistin against 64.7 and 11.8% of tested isolates, while the combination with gentamicin resulted in indifference. All studied combinations showed improved bactericidal activity, compared to fosfomycin alone and prevented the development of fosfomycin resistance in 69.2, 53.8, and 81.8% of susceptible isolates, respectively.

Full Text

Cited Authors

  • Souli, M; Galani, I; Boukovalas, S; Gourgoulis, MG; Chryssouli, Z; Kanellakopoulou, K; Panagea, T; Giamarellou, H

Published Date

  • May 2011

Published In

Volume / Issue

  • 55 / 5

Start / End Page

  • 2395 - 2397

PubMed ID

  • 21321144

Pubmed Central ID

  • 21321144

Electronic International Standard Serial Number (EISSN)

  • 1098-6596

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.01086-10


  • eng