Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae and Escherichia coli isolates possessing blaVIM-1 in Greece.


Journal Article

Amongst nalidixic acid-resistant, ciprofloxacin-susceptible Escherichia coli and Klebsiella pneumoniae clinical isolates recovered over a 5-month period from inpatients and outpatients of Attikon University General Hospital (Athens, Greece), only one E. coli was positive for qnrB2 and one K. pneumoniae was positive for qnrA1. Both isolates were extended-spectrum beta-lactamase-negative, metallo-beta-lactamase-positive and carried the bla(VIM-1) gene. Neither of the isolates had mutations in gyrA and parC or carried aac(6')-Ib-cr or qepA. The K. pneumoniae isolate also harboured bla(CMY-13) on the same transferable plasmid with qnrA1. This is the first report of a qnrA1-positive K. pneumoniae and qnrB2-positive E. coli harbouring a concurrent bla(VIM-1) gene.

Full Text

Cited Authors

  • Galani, I; Souli, M; Mitchell, N; Chryssouli, Z; Giamarellou, H

Published Date

  • September 2010

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 252 - 254

PubMed ID

  • 20580536

Pubmed Central ID

  • 20580536

Electronic International Standard Serial Number (EISSN)

  • 1872-7913

International Standard Serial Number (ISSN)

  • 0924-8579

Digital Object Identifier (DOI)

  • 10.1016/j.ijantimicag.2010.05.004


  • eng