Use of Direct Oral Anticoagulants in Special Populations.

Journal Article (Journal Article;Review)

Direct oral anticoagulants (DOACs) have been approved for the treatment of venous thromboembolism and atrial fibrillation based on randomized controlled trials (RCTs) of direct comparisons with vitamin K antagonists. Despite having more than 100,000 patients enrolled, safety and efficacy are debated in selected populations. Although DOACs are reviewed as a class of anticoagulant, pharmacokinetic differences exist such that different medications may be beneficial in distinct clinical settings. Synthesizing available evidence based on phase III RCTs, post hoc subgroup analyses, and pooled metaanalyses, this review provides an overview of DOACs and scrutinizes individual differences in their applications for the special populations.

Full Text

Duke Authors

Cited Authors

  • Li, A; Lopes, RD; Garcia, DA

Published Date

  • October 2016

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 1053 - 1071

PubMed ID

  • 27637307

Electronic International Standard Serial Number (EISSN)

  • 1558-1977

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2016.05.003


  • eng

Conference Location

  • United States