Genomics of PTSD

Published

Book Section

© 2016 by John Wiley & Sons, Inc. All rights reserved. This chapter summarizes available literature on the genetics of posttraumatic stress disorder (PTSD) and highlights scientific research in animal models and humans related to the identification of genetic risk factors for PTSD. Since trauma exposure is a prerequisite for diagnosis of PTSD, the chapter discusses how genetic predisposition can moderate the environmental impact on disease. It presents an overview of candidate-based and genome-wide association studies as well as gene-environment interaction studies performed in humans to date. Additionally, the chapter describes potential epigenetic mechanisms in tandem with gene expression results that provide new models for how the environment influences PTSD risk by modification of genetic contributions to PTSD. Future studies offer a systems-level understanding of how multiple genes and biological pathways interact with traumatic events to determine distinct outcomes among individuals. Such integrative studies pave the way for a better understanding of genomics and subsequently treatment of PTSD.

Full Text

Duke Authors

Cited Authors

  • Zannas, AS; Binder, E; Mehta, D

Published Date

  • January 1, 2016

Book Title

  • Posttraumatic Stress Disorder: From Neurobiology to Treatment

Start / End Page

  • 233 - 264

International Standard Book Number 13 (ISBN-13)

  • 9781118356111

Digital Object Identifier (DOI)

  • 10.1002/9781118356142.ch10

Citation Source

  • Scopus